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KMID : 1189420130260010075
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2013 Volume.26 No. 1 p.75 ~ p.81
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The effect of Astragalus membranaceus methanol extract on hyaluronic acid production in HaCaT cells
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Lee Pyeong-Jae
Kim Hee-Taek
Yoon Kyung-Sup
Park Hyun-Chul
Ha Hun-Yong
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Abstract
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Objectives: Hyaluronic acid, high molecular glycosaminoglycan, exists in extracellular matrix of tissue, especially, in skin and has been known to be deeply involved in skin hydration. In this study, we investigated the effect of methanol extract of Hwang-gi, Astragalus membranaceus root, on hyaluronic acid production in human keratinocyte HaCaT cells.
Methods: We determined hyaluronic acid synthase 2 gene expression and hyaluronic acid production in HaCaT cells by using RT-PCR and ELISA, respectively.
Results: Hwang-gi extract didn't show the toxicity to HaCaT cells within the treated concentration and increased the hyaluronic acid synthase 2 gene expression and hyaluronic acid production.
Conclusions: Hyaluronic acid production increased by Hwang-gi could be, partially, contribute to the moisturing effect in skin by it.
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KEYWORD
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Astragalus membranaceus, Hyaluronic acid, Hyaluronic aid synthase, HaCaT
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